Open AccessNeutrophil priming: Implications in periodontal disease
Author(s) -
Radhika Shah,
Raison Thomas,
Dhoom Singh Mehta
Publication year - 2017
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/jisp.jisp_385_15
Subject(s) - medicine , immunology , periodontitis , pathogenesis , rheumatoid arthritis , disease , periodontal disease , priming (agriculture) , immune system , ards , inflammatory response , host response , inflammation , lung , pathology , biology , botany , germination
Periodontal disease is a well-regulated response to bacterial infection directed by the inflammatory cells of the host immune system. The host response to injury or insult is implicated to be a vital feature of the majority of periodontal diseases. The excessive activation of neutrophils plays a role in the pathogenesis in diseases such as acute respiratory distress syndrome, rheumatoid arthritis, and periodontitis by contributing to inflammatory tissue injury. In the recent times, there has been a shift of paradigm from a hypo- to hyper-responsive/primed model of neutrophil dysfunction in periodontal etiopathogenesis. The aim of this review is to outline the mechanisms and effects of neutrophil priming, and thereafter, discuss the current controversy that exists regarding the role of primed neutrophils in periodontal etiopathogenesis.