Evaluation of collagenase-3 matrix metalloproteinase-13 gene-associated polymorphisms 11A/12A and −77A/G and its associated alleles with and without periodontitis | Zendy

JammulaSurya Prasanna | Zendy; MutyapDivya Aishwarya | Zendy; P Karunakar | Zendy; Rekha Rani Koduganti | Zendy; Vijaya Lakshmi Bodiga | Zendy; Jharna Puppala | Zendy

Open Access

Evaluation of collagenase-3 matrix metalloproteinase-13 gene-associated polymorphisms 11A/12A and −77A/G and its associated alleles with and without periodontitis

Author(s) -

JammulaSurya Prasanna,

MutyapDivya Aishwarya,

P Karunakar,

Rekha Rani Koduganti,

Vijaya Lakshmi Bodiga,

Jharna Puppala

Publication year - 2018

Publication title -

journal of indian society of periodontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.309

H-Index - 28

eISSN - 0975-1580

pISSN - 0972-124X

DOI - 10.4103/jisp.jisp_333_18

Subject(s) - collagenase , genotype , allele , matrix metalloproteinase , interstitial collagenase , medicine , microbiology and biotechnology , periodontitis , gene polymorphism , genetics , allele frequency , gastroenterology , gene , immunology , biology , enzyme , biochemistry

Connective tissue devastation in periodontitis and other chronic inflammatory diseases is a major concern. There are several inflammatory mediators associated with this process among which matrix metalloproteinases (MMPs) play a predominant role. Collagen degradation is primarily mediated by the collagenases. MMP-13 is familiar as collagenase-3, which has the aptitude to humiliate fibrillar collagen.

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