Open AccessEvaluation of collagenase-3 matrix metalloproteinase-13 gene-associated polymorphisms 11A/12A and −77A/G and its associated alleles with and without periodontitis
Author(s) -
Jammula Surya Prasanna,
Mutyap Divya Aishwarya,
Pediredla Karunakar,
Koduganti Rekharani,
Vijaya Lakshmi Bodiga,
Jharna Puppala
Publication year - 2018
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/jisp.jisp_333_18
Subject(s) - collagenase , genotype , allele , matrix metalloproteinase , interstitial collagenase , medicine , microbiology and biotechnology , periodontitis , gene polymorphism , genetics , allele frequency , gastroenterology , gene , immunology , biology , enzyme , biochemistry
Connective tissue devastation in periodontitis and other chronic inflammatory diseases is a major concern. There are several inflammatory mediators associated with this process among which matrix metalloproteinases (MMPs) play a predominant role. Collagen degradation is primarily mediated by the collagenases. MMP-13 is familiar as collagenase-3, which has the aptitude to humiliate fibrillar collagen.