Open AccessAdult multifocal Langerhan's cell histiocytosis involving periodontal tissues
Author(s) -
Vijay Kumar Chava,
Vellampalli Udhaya Bhanu
Publication year - 2021
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/jisp.jisp_22_20
Subject(s) - langerhans cell histiocytosis , pathology , cd68 , medicine , langerin , histiocytosis , lesion , spleen , birbeck granules , langerhans cell , infiltration (hvac) , bone marrow , dental alveolus , immunohistochemistry , immune system , dendritic cell , immunology , physics , disease , dentistry , thermodynamics
Langerhans cell histiocytosis (LCH) is a rare inflammatory neoplasia characterized by uncontrolled stimulation and abnormal proliferation of Langerhans cells (LCs). It can present as unifocal or multifocal with local and systemic manifestations which involves various internal organs and mucosal tissues. The clinical course varies among individuals, ranges from spontaneous resolution to life-threatening conditions with multisystem involvement. Prognosis relies on the involvement of risk organs (liver, spleen, and bone marrow) at diagnosis, mainly on organ dysfunction, and response to initial therapy. The diagnosis is based on histological study of tissues samples and shows tissue infiltration with LCs and the tumor cells immunopositive for s100/CD1a/Langerin/CD68 focal). In the oral cavity, LCH affects the alveolar or cortical bone and causes ulcerated lesions involving various mucosal and periodontal tissues. This article reports a case of adult multifocal LCH involving periodontal tissues with 1½ year posttreatment follow-up showing regression of the lesion.