Open AccessHepatoblastoma with precocious puberty
Author(s) -
Eo Yhoshu,
Yasir Ahmad Lone,
Jai Kumar Mahajan,
Uday Pal Singh
Publication year - 2019
Publication title -
journal of indian association of pediatric surgeons
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.306
H-Index - 17
eISSN - 1998-3891
pISSN - 0971-9261
DOI - 10.4103/jiaps.jiaps_102_18
Subject(s) - virilization , hepatoblastoma , precocious puberty , medicine , testosterone (patch) , human chorionic gonadotropin , endocrinology , hormone , luteinizing hormone , alpha fetoprotein , androgen , hepatocellular carcinoma
Hepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious puberty wherein hormonal assays showed an increase in α-FP, β-hCG, and testosterone levels, and suppression of follicle-stimulating and luteinizing hormone levels. After chemotherapy and surgery, α-FP, β-hCG, and testosterone levels normalized, and the signs of virilization did not progress further. New therapeutic approaches have made a previously reported grim prognosis of virilizing HB, more favorable now. In the assessment of PPP, the possibility of a tumoral source for the hormones should also be considered.