Open AccessEffect of insulin sensitizers on raised serum anti-mullerian hormone levels in infertile women with polycystic ovarian syndrome
Author(s) -
Neeti Chhabra,
Sonia Malik
Publication year - 2018
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/jhrs.jhrs_59_17
Subject(s) - anti müllerian hormone , anovulation , medicine , hyperandrogenism , antral follicle , polycystic ovary , luteinizing hormone , infertility , insulin resistance , gynecology , metformin , ovarian reserve , endocrinology , insulin , hormone , pregnancy , biology , genetics
Increased circulating insulin levels contribute to hyperandrogenism in polycystic ovarian syndrome (PCOS) which causes a derangement in folliculogenesis, thus contributing to polycystic morphogenesis of the ovaries and a higher than normal anti-Mullerian hormone (AMH). A high AMH is an indicator of either stubborn anovulation or a predictor of ovarian hyperstimulation syndrome. Hence, it is postulated that the use of insulin sensitizers will reduce insulin resistance, hyperandrogenism, and subsequently serum AMH levels and will convert anovulatory cycles to ovulatory.