Open AccessClinical manifestations of chromosomal anomalies and polymorphic variations in patients suffering from reproductive failure
Author(s) -
Leena Rawal,
Sumit Kumar,
Shiba Mishra,
Vandana Lal,
Sumitra Bhattacharya
Publication year - 2020
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/jhrs.jhrs_46_19
Subject(s) - chromosomal translocation , biology , robertsonian translocation , genetics , karyotype , heterochromatin , cytogenetics , chromosome , chromosomal inversion , supernumerary , chromosomal rearrangement , gene , anatomy
Human reproduction is the most intricate event as ~ 20% of human pregnancies end in miscarriages for which chromosomal anomalies are a common factor. The chromosomal variations associated with reproductive failures include translocations, inversions, supernumerary marker chromosomes, heterochromatic polymorphisms, etc., Till date, the significance of heteromorphic variants in reproductive failures is unclear.