Open AccessThe effect of sperm DNA fragmentation index on the outcome of intrauterine insemination and intracytoplasmic sperm injection
Author(s) -
N Siddhartha,
Nellepalli Sanjeeva Reddy,
Monna Pandurangi,
Tamizharasi Muthusamy,
Radha Vembu,
Kanimozhi Kasinathan
Publication year - 2019
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/jhrs.jhrs_22_19
Subject(s) - intracytoplasmic sperm injection , intrauterine insemination , dna fragmentation , insemination , andrology , sperm , donor insemination , sperm washing , chemistry , gynecology , in vitro fertilisation , biology , medicine , pregnancy , artificial insemination , pregnancy rate , genetics , apoptosis , programmed cell death
Elevated sperm DNA fragmentation index (DFI) is found to affect normal embryonic development, implantation and fetal development after intrauterine insemination (IUI), in vitro fertilization and intracytoplasmic sperm injection (ICSI). Estimation of DFI by terminal deoxynucleotidyl transferase-mediated fluorescent deoxy uridine nucleotide nick end labeling (TUNEL) assay was found to have a high predictive value for pregnancy after fertility treatments.