Open AccessImpact of intrauterine administration of human chorionic gonadotropin before intrauterine insemination in infertile women: A randomized controlled trial
Author(s) -
Leena Wadhwa,
Anupama Rani
Publication year - 2021
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/jhrs.jhrs_196_20
Subject(s) - medicine , gynecology , pregnancy rate , human chorionic gonadotropin , randomized controlled trial , miscarriage , corpus luteum , pregnancy , obstetrics , in vitro fertilisation , andrology , biology , hormone , genetics
Implantation is the rate-limiting step in the success of both intrauterine Insemination (IUI) and in vitro fertilization cycles. Numerous interventions that target various local signals have been tried to improve the implantation and clinical pregnancy rate (CPR). The most significant of these signals is human chorionic gonadotropin (hCG) which acts as immunomodulator and improves implantation by decidualization of the endometrial stromal cells, trophoblast invasion, proliferation of uterine natural killer cells, stimulation of endometrial angiogenesis, and maintenance of progesterone secretion by the corpus luteum.