Open AccessComplete androgen insensitivity syndrome: Dilemmas for further management after gonadectomy
Author(s) -
Pratibha Singh,
Meenakshi Gothwal,
Garima Yadav,
Kuldeep Singh
Publication year - 2019
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/jhrs.jhrs_151_18
Subject(s) - geneticist , androgen insensitivity syndrome , medicine , complete androgen insensitivity syndrome , androgen , hormone replacement therapy (female to male) , genetic counseling , pediatrics , genetic condition , intensive care medicine , gynecology , bioinformatics , testosterone (patch) , endocrinology , hormone , prostate cancer , androgen receptor , genetics , cancer , biology
Complete androgen insensitivity syndrome is a rare condition, wherein a genetic male is phenotypically female and is raised as a female. Treatement requires timely gonadectomy, need for long term hormonal replaceent therapy, psycological and genetic counseling. The type, dose, duration of hrt is not well studied. Reproductive issues also need to be addressed in these young woman. We report here a case of complete androgen insensitivity which posed a quandary for management of long term bone health. Review of literature for management is discussed. These cases are best managed by a multi-disciplenary team comprising of gynecologist, geneticist, endocrinologist and clinical psycologist or psychiatrist.