Open AccessScreening of polymorphisms of transcription factor 7-like 2 gene in polycystic ovary syndrome using polymerase chain reaction-restriction fragment length polymorphism analysis
Author(s) -
Yogamaya D Prabhu,
Nishu Sekar,
V G Abilash
Publication year - 2018
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/jhrs.jhrs_123_15
Subject(s) - polycystic ovary , tcf7l2 , genotype , restriction fragment length polymorphism , biology , genotyping , genetics , polymerase chain reaction , promoter , gene , endocrinology , diabetes mellitus , insulin resistance , single nucleotide polymorphism , gene expression
Polycystic ovary syndrome (PCOS) is a common endocrine disorder occurring in premenopausal women, with a prevalence rate of 5%-7%. It has been observed in multiple number of studies the coexistence between diabetes mellitus 2 and obesity with this endocrinopathic disorder. Transcription factor 7-like 2 (TCF7L2) gene is shown to be associated with insulin secretion.