Open AccessGenetics of female infertility: Molecular study of newborn ovary homeobox gene in poor ovarian responders
Author(s) -
Osamah Batiha,
Nour Alhoda Alahmad,
Amer Sindiani,
Khaldon Bodoor,
Sherin Shaaban,
Mohammad Al-Smadi
Publication year - 2019
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/jhrs.jhrs_112_18
Subject(s) - biology , single nucleotide polymorphism , genetics , gene , genotype , loss of heterozygosity , allele , homeobox , transcription factor
Newborn ovary homeobox ( NOBOX ) gene plays a critical role in the transcriptional regulation of oocyte-specific genes. Previous studies have demonstrated a pathogenic effect of NOBOX variants on premature ovarian insufficiency (POI) patients. Poor ovarian response (POR) is a risk factor for POI. Therefore, genetic variants in the NOBOX gene may also be studied as risk factors for POR development.