Open AccessClonal lineage diversity, antibiotic resistance, and virulence determinants among methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolated from nurses at a teaching hospital in Ilam, Iran: Successful nares decolonization by mupirocin
Author(s) -
Ali Hematian,
Aazam Monjezi,
Ramin Abiri,
Parviz Mohajeri,
Abbas Farahani,
Setareh Soroush,
Morovat Taherikalani
Publication year - 2018
Publication title -
journal of global infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 25
eISSN - 0974-8245
pISSN - 0974-777X
DOI - 10.4103/jgid.jgid_43_17
Subject(s) - mupirocin , pulsed field gel electrophoresis , anterior nares , staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , multilocus sequence typing , carriage , antibiotic resistance , typing , medicine , antibiotics , virulence , biology , bacteria , genotype , gene , genetics , biochemistry , pathology
Staphylococcus aureus is known to be responsible for nosocomial infections, and the typing method was useful in managing the reservoir of bacteria. The main aim of this study was to determine the prevalence of S. aureus in the nares and hands of nurses working in Imam Khomeini hospital, Ilam, Iran, as well as to determine the clonal relatedness, antimicrobial susceptibility profiles, different virulence, and resistance determinants among these isolates. The evolution of mupirocin activity in the eradication of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) colonization in the nares of the healthcare workers in Ilam, Iran, was also determined in this study.