Open AccessCirculating adropin and vascular endothelial growth factor receptor-2 levels in age-related macular degeneration and T2DM patients—A cross-sectional study
Author(s) -
Areekulangara Neethu,
Kuppuswami Jayashree,
Gandhipuram Periyasamy Senthilkumar,
K Ramesh Babu,
Vadivelan Mehalingam
Publication year - 2020
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_813_20
Subject(s) - medicine , macular degeneration , diabetes mellitus , vascular endothelial growth factor , blood lipids , angiogenesis , endocrinology , cholesterol , ophthalmology , vegf receptors
Macular drusen formation and angiogenesis are the two chief processes associated with age-related macular degeneration. Adropin and vascular endothelial growth factor receptor-2 (VEGFR-2) may be involved in these pathologies. By altering lipid metabolism, adropin may contribute in the early stages of age-related macular degeneration (AMD). VEGFR-2 may participate in the later form of AMD, by promoting angiogenesis. This study compared the circulatory levels of adropin and VEGFR-2 in AMD and patients without AMD and assessed their association with disease severity, to understand their possible role in AMD.