Open AccessRole of microRNAs in stroke recovery
Author(s) -
Agam Bansal,
Rana Prathap,
Samiksha Gupta,
Aditi Chaurasia
Publication year - 2019
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_296_19
Subject(s) - medicine , stroke (engine) , neuroprotection , stroke recovery , neurogenesis , microrna , spontaneous recovery , angiogenesis , neuroplasticity , ischemic stroke , neuroscience , physical medicine and rehabilitation , intensive care medicine , bioinformatics , rehabilitation , physical therapy , ischemia , anesthesia , psychiatry , mechanical engineering , biochemistry , chemistry , gene , engineering , biology
Ischemic stroke is an important cause of morbidity and mortality across the globe. It is associated with physical, social, and economic disability. Immediately after the stroke, there is a critical period of spontaneous recovery during which there is maximal return to near normal. Following stroke, there is a period of neurogenesis, angiogenesis, axonal growth, and synaptic plasticity. There have been several studies focusing on neuroprotection and enhancing recovery following stroke. However, translation of these into clinical practice has been disappointing. The role of microRNAs in treatment of cancer has been well documented, but studying their role in stroke recovery has been minimal. MicroRNAs serve as critical mediators of recovery following stroke. In this review article, we discuss the role of microRNAs in stroke recovery.