Open AccessFulminant dengue hepatitis in sickle cell disease: Recovery against the odds
Author(s) -
Divit Shah,
Dhruv Talwar,
Sunil Kumar,
Sourya Acharya,
Vidyashree Hulkoti
Publication year - 2022
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_2058_21
Subject(s) - medicine , fulminant hepatic failure , fulminant , dengue fever , asymptomatic , fulminant hepatitis , jaundice , disease , hepatitis , immunology , liver disease , gastroenterology , liver transplantation , transplantation
Fulminant hepatitis is a potentially life-threatening disease that is evident through the findings of organ dysfunction, jaundice, and hepatomegaly, which is painful. Dysfunction of the endothelial cells and thus the damage of the endothelium is the probable mechanism, which is responsible for causing complications of hepatobiliary system in patients with sickle cell disease. Various acute as well as chronic manifestations of the hepatobiliary system, having varied severity and pathophysiology are associated with sickle cell disease. Dengue fever may also affect the liver starting from asymptomatic liver enzyme derangement to fulminant hepatic failure. This case series describes the first ever association of fulminant hepatic failure resulting from the synergistic effect of dengue fever with sickle cell disease and thus highlights the importance of prevention of dengue fever in sickle cell patients, thereby preventing potentially lethal fulminant hepatic failure.