Open AccessPemphigus vulgaris – A report of three cases and review of literature
Author(s) -
Ishita Banerjee,
Biyas Bhowmik,
Anirban Maji,
Rupam Sinha
Publication year - 2018
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_133_18
Subject(s) - acantholysis , pemphigus vulgaris , medicine , desmoglein 3 , dermatology , autoantibody , desmoglein , pemphigus , immunology , antibody
Pemphigus vulgaris (PV) is an autoimmune, potentially life-threatening disease causing blisters and erosions of the skin and mucous membranes associated with intraepithelial acantholysis. The underlying mechanism responsible for causing intraepithelial lesions is the binding of immunoglobulin G autoantibodies to desmoglein 3, a transmembrane glycoprotein adhesion molecule present on desmosomes. Histological features comprise intraepithelial cleft and Tzanck cells. Corticosteroids remain the mainstay of the treatment plan. In this article, we have discussed about the diagnosis of three patients suffering from PV, the treatment rendered, and the outcome of the same.