Open AccessThe synergistic cytotoxic effects of doxorubicin and Viola odorata extract on human breast cancer cell line T47-D
Author(s) -
Shirin Zeinoddini,
Mohammad Nabiuni,
Hanieh Jalali
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_990_17
Subject(s) - doxorubicin , mtt assay , cytotoxic t cell , pharmacology , medicine , breast cancer , cancer , cancer cell , mcf 7 , flow cytometry , apoptosis , traditional medicine , chemotherapy , chemistry , human breast , immunology , in vitro , biochemistry
Breast cancer accounts for one-third of cancer cases in women. Doxorubicin (Dox) is one of the chemotherapeutical compounds widely used to treat breast cancer. Chemical drugs have several side effects and their continuous administration leads to drug resistance in patients. To decrease such side effects in cancer treatment, combination therapy as well as application of natural and herbal compounds has been taken into consideration. The aim of this study was to investigate the cytotoxic effect of Viola odorata (Vo) extract on T47-D human breast cancer cells, alone and in combination with Dox.