Open AccessTargeting EZH2 depletes LMP1-induced activated regulatory T cells enhancing antitumor immunity in nasopharyngeal carcinoma
Author(s) -
Wei Sun,
Lin Chen,
Jun Tang,
Chengcheng Zhang,
Yihui Wen,
Weiping Wen
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_986_19
Subject(s) - nasopharyngeal carcinoma , cancer research , ezh2 , antigen , foxp3 , flow cytometry , biology , in vitro , in vivo , immune system , immunology , medicine , gene expression , radiation therapy , biochemistry , microbiology and biotechnology , gene
Regulatory T cells (Tregs) are critical factors that impair antitumor immunity. Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is one of the most pathogenic factors in nasopharyngeal carcinoma (NPC). However, the role of EBV-encoded LMP1 in regulating Treg generation in NPC remains unclear.