Open AccessA correlation of immunohistochemical expression of TP53 and severity of inflammation with varying grades of oral squamous cell carcinoma
Author(s) -
Jay Ashokkumar Pandya,
Srikant Natarajan
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_8_17
Subject(s) - inflammation , carcinogenesis , immunohistochemistry , pathology , malignancy , grading (engineering) , cancer , cell , immune system , biopsy , medicine , biology , cancer research , immunology , ecology , genetics
Epithelial cells exposed to carcinogens and genetic damage, once surpass reversible cell damage, either undergo apoptosis or transform into malignancy, chiefly oral squamous cell carcinoma (OSCC). Progressive accumulation of genetic errors in TP53 results in tumorigenesis. Inflammation is also a modulator in this process. The present study attempted to correlate the immunohistochemical expression of TP53 with increased aggressiveness of OSCC, to determine how these immune cells regulate the path of carcinogenesis and to define the role of inflammation in TP53 immunoexpression.