Open AccessExpression of major histocompatibility complex class I polypeptide-related sequence B in adipose-derived stem cells from breast cancer patients and normal individuals
Author(s) -
Zahra Mansourabadi,
Mahboobeh Razmkhah,
Maryam Sadat Mohtasebi,
Abdolrasoul Talei,
Abbas Ghaderi
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_866_16
Subject(s) - biology , stem cell , adipose tissue , nkg2d , major histocompatibility complex , cancer research , breast cancer , immunology , immune system , cancer , microbiology and biotechnology , cytotoxic t cell , endocrinology , in vitro , genetics
Through the expression of different immunomodulatory molecules, mesenchymal stem cells (MSCs) play a significant role in the regulation of immune responses against tumor cells. Herein, the expression of major histocompatibility complex class I polypeptide-related sequence B (MIC B) as an immunomodulatory molecule was investigated on adipose-derived stem cells (ASCs) isolated from breast cancer patients (Stage II and III) and healthy individuals.