Open AccessSelenocystine inhibits JEG-3 cell growth in vitro and in vivo by triggering oxidative damage-mediated S-phase arrest and apoptosis
Author(s) -
Ming Zhao,
YaJun Hou,
Xiaoting Fu,
Dawei Li,
Jingyi Sun,
Xin Fu,
Zhigang Wei
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_864_17
Subject(s) - apoptosis , viability assay , cell cycle , chemistry , cell growth , reactive oxygen species , dna damage , cell cycle checkpoint , in vivo , oxidative stress , microbiology and biotechnology , flow cytometry , biology , biochemistry , dna
Selenocystine (SeC) is a nutritionally available selenoamino acid presenting novel anticancer potential against human cancers. However, neither the effects nor mechanism of SeC against choriocarcinoma growth has been clarified yet. This study investigated the anticancer effects and mechanism of SeC against JEG-3 human choriocarcinoma growth in vitro and in vivo.