Open AccessDetection of novel infiltrating ductal carcinoma-associated BReast CAncer gene 2 mutations which alter the deoxyribonucleic acid-binding ability of BReast CAncer gene 2 protein
Author(s) -
Lateef Ullah,
Yasir Hameed,
Samina Ejaz,
Anam Raashid,
Jamshed Iqbal,
Inam Ullah,
Syeda Abida Ejaz
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_861_19
Subject(s) - breast cancer , cancer , nonsense mutation , mutation , ductal carcinoma , biology , cancer research , gene , microbiology and biotechnology , medicine , genetics , missense mutation
BReast CAncer gene 2 (BRCA2), a tumor suppressor gene located on chromosome 13q, encodes a 384-kDa protein which activates homologous recombination pathway to repair ssDNA damage.