Open AccessMechanisms correlated with chemotherapy resistance in tongue cancers
Author(s) -
Guanghong Han,
Chengbi Xu,
Dan Yu
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_763_17
Subject(s) - tongue , cancer , medicine , head and neck cancer , head and neck , tongue neoplasm , drug resistance , oncology , incidence (geometry) , chemotherapy , bioinformatics , pathology , surgery , biology , genetics , physics , optics
Tongue cancer is one of the most common and deadly types of head and neck cancer. The incidence of tongue cancer has been particularly high and remained been increasing in some countries. A main reason for poor prognosis and clinical outcome for tongue cancer was its resistance to chemotherapies, behind which the mechanisms have been not clear. In this review, we summarized literatures published in recent years and listed the proteins, biomacromolecules, and signaling pathways related to this drug resistance. We hoped that this summary could provide reference for researchers to develop new treatment strategies for tongue cancer.