Open AccessGood prognostic factor in patients with nonmetastatic nasopharyngeal carcinoma: Programmed death ligand-1 expression in tumor cells
Author(s) -
Hayriye Şahinli,
Nalân Akyürek,
Mukaddes Yılmaz,
Olcay Kandemir,
Ayşe Ocak Duran,
Sezer Kulaçoğlu,
Gökhan Uçar,
Elif Esma Acar,
Ahmet Özet,
Ömür Berna Öksüzoğlu,
Nuriye Özdemir
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_759_19
Subject(s) - immunohistochemistry , medicine , hazard ratio , pd l1 , nasopharyngeal carcinoma , oncology , univariate analysis , proportional hazards model , cancer , survival analysis , immunotherapy , confidence interval , pathology , multivariate analysis , radiation therapy
Programmed death ligand-1 (PD-L1) is the main ligand for programmed death-1 (PD-1), and is one of the major targets for cancer immunotherapy. Only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). There is a controversial association between PD-L1 expression and survival in NPC. This study aimed at defining any potential association between PD-L1 expression in tumor cells (TCs) and prognosis in NPC.