Open AccessIncreased expression of epidermal growth factor-like domain-containing protein 7 is predictive of poor prognosis in patients with hepatocellular carcinoma
Author(s) -
Chao Yang,
Yunliang Wang,
Ding-Ping Sun,
Xiaoli Zhu,
Zhi Li,
Caifang Ni
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_745_17
Subject(s) - hepatocellular carcinoma , cirrhosis , immunohistochemistry , epidermal growth factor , metastasis , hypoxia (environmental) , vascular endothelial growth factor , pathology , medicine , biomarker , biology , cancer , cancer research , chemistry , receptor , vegf receptors , biochemistry , organic chemistry , oxygen
Epidermal growth factor-like domain-containing protein 7 (EGFL7) is an endothelial cell-derived secreted factor that regulates vascular tube formation. In human cancer, the specificity of expression is lost as EGFL7 has been detected in tumor cells, in addition to endothelial cells. This study evaluated the intricate relationship between hypoxia-inducible factor 1-alpha (HIF-1α) and EGFL7 under both hyperoxia and hypoxia states.