Open AccessAntiangiogenic activity of zinc and zinc-sorafenib combination using the chick chorioallantoic membrane assay: A descriptive study
Author(s) -
Manish Kumar,
Girish Gulab Meshram,
Tripti Rastogi,
Sonal Sharma,
Rachna Gupta,
Seema Jain,
Anisha Prasad,
Vikas Galav,
Swapan Kumar Bhattacharya
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_737_16
Subject(s) - sorafenib , chorioallantoic membrane , embryo , zinc , pharmacology , chemistry , andrology , biology , medicine , microbiology and biotechnology , hepatocellular carcinoma , organic chemistry
Zinc, a trace element, is known for downregulating several proangiogenic growth factors and cytokines. However, its antiangiogenic activity is not adequately studied. The present study was aimed to evaluate the possible antiangiogenic activity of zinc via the chick chorioallantoic membrane (CAM) assay. Furthermore, the antiangiogenic activity of the combination therapy of zinc with various doses of sorafenib, a tyrosine kinase inhibitor, was evaluated.