Open AccessThe role of NRAGE subcellular location and epithelial–mesenchymal transition on radiation resistance of esophageal carcinoma cell
Author(s) -
Xiaojing Chang,
Xiaoying Xue,
Yafang Zhang,
Ge Zhang,
Huandi Zhou,
Yanling Yang,
Yu-Ge Ran,
Zhiqing Xiao,
Xiaohui Ge,
Huizhi Liu
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_687_17
Subject(s) - epithelial–mesenchymal transition , cancer research , vimentin , downregulation and upregulation , radioresistance , cell culture , chemistry , mesenchymal stem cell , cell , cell migration , pathology , medicine , immunohistochemistry , biology , gene , biochemistry , genetics
Neurotrophin receptor-interacting MAGE homolog (NRAGE) has been considered as a tumor suppressor. In the previous study, we established human esophageal carcinoma resistance cell line TE13R120 and found the difference of NRAGE expression between TE13 and TE13R120 cells by gene microarray. Herein, we further discuss the possible molecular mechanism of NRAGE on participating the radiation sensitivity of esophageal carcinoma cells.