Open AccessConcomitant echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation in non-small cell lung cancer patients from eastern India
Author(s) -
Prasanta Raghab Mohapatra,
Shraban Kumar Sahoo,
Sourin Bhuniya,
Manoj Kumar Panigrahi,
Saroj Kumar Das Majumdar,
Pritinanda Mishra,
Susama Patra
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_678_18
Subject(s) - anaplastic lymphoma kinase , epidermal growth factor receptor , medicine , cancer research , concomitant , lung cancer , adenocarcinoma , tyrosine kinase inhibitor , crizotinib , oncology , targeted therapy , cancer , malignant pleural effusion
In non-small cell lung cancer common driver mutations such as epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) are usually mutually exclusive. This study aimed to elucidate the concurrence of EGFR mutation and ALK rearrangement in eastern India patients with primary lung adenocarcinoma and assess the response of EGFR tyrosine kinase inhibitor (TKI) therapy after 6 months in primary lung adenocarcinoma.