Open AccessHeparan sulfate D-glucosamine 3-O-sulfotransferase 3B1 is a novel regulator of transforming growth factor-beta-mediated epithelial-to-mesenchymal transition and regulated by miR-218 in nonsmall cell lung cancer
Author(s) -
Zengli Zhang,
Hanyi Jiang,
Yongsheng Wang,
Minhua Shi
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_659_17
Subject(s) - epithelial–mesenchymal transition , mesenchymal stem cell , cancer research , metastasis , downregulation and upregulation , phenotype , biology , cell culture , cell growth , cell , cancer , chemistry , microbiology and biotechnology , gene , biochemistry , genetics
Due to high metastasis and recurrence rate. Recent studies indicated that epithelial-to-mesenchymal transition (EMT) was involved in the progression and metastasis in cancer. Some reports also indicate that HS3ST3B1 played a role in angiogenesis and the proliferation of cancer cells. In this study, we aim to investigate its role in non-small cell lung cancer (NSCLC) .