Open AccessAcinic cell carcinoma of the parotid gland with neuroendocrine differentiation
Author(s) -
Ashutosh Rath,
Reena Tomar,
Rishu Agarwal,
Meeta Singh,
Shyama Jain,
Nita Khurana,
Praveen Kumar Rathore
Publication year - 2021
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_645_19
Subject(s) - acinic cell carcinoma , parotid gland , neuroendocrine differentiation , immunohistochemistry , neuroendocrine carcinoma , pathology , salivary gland , carcinoma , neuroendocrine tumors , medicine , mucoepidermoid carcinoma , cancer , prostate cancer
Acinic cell carcinoma (ACC) is a malignant salivary gland tumor characterized by tumor cells displaying acinar features. Usually presenting as a slow-growing tumor, ACC, however, may show dedifferentiation to a higher grade including neuroendocrine carcinoma. In addition, ACC may rarely show focal neuroendocrine differentiation without any frank evidence of neuroendocrine carcinoma. We describe such a case of ACC of the parotid gland in a 65-year-old female, which showed neuroendocrine differentiation. The diagnostic clues, immunohistochemistry panel, and prognostic and treatment aspects are also presented.