Open AccessEpigenetic deregulations of Wnt/β-catenin and transforming growth factor beta-Smad pathways in esophageal cancer: Outcome of DNA methylation
Author(s) -
Virendra Singh,
Avninder Singh,
Ira Sharma,
Laishram Chandreshwor Singh,
Jagannath Dev Sharma,
Bibhuti Bhusan Borthakar,
Avdhesh Kumar,
Amal Chandra Kataki,
Sujala Kapur,
Sunita Saxena
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_634_17
Subject(s) - cdh1 , cancer research , dna methylation , carcinogenesis , epigenetics , biology , wnt signaling pathway , methylation , population , microbiology and biotechnology , cancer , gene expression , signal transduction , medicine , genetics , gene , cell , cadherin , environmental health
Promoter methylation of tumor suppressor genes (TSGs) is a well-reported portent in carcinogenesis; hence, it is worthy to investigate this in high-risk Northeast population of India. The study was designed to investigate methylation status of 94 TSGs in esophageal squamous cell carcinoma (ESCC). Further, the effect of OPCML promoter methylation on gene expression was analyzed by immunohistochemistry. Moreover, in silico protein-protein interactions were examined among 8 TSGs identified in the present study and 23 epigenetically regulated genes reported previously by our group in ESCC.