Open AccessA study on the antitumor effect of gemcitabine polybutylcy- anoacrylate nanoparticles coupled with Mucin 1 monoclonal antibody on pancreatic cancer in vitro and in vivo
Author(s) -
Lin Zhang,
Zhu Jianhua,
Yayi Hou,
Chunmei Li,
Haorun Liu
Publication year - 2021
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_627_21
Subject(s) - gemcitabine , in vivo , muc1 , pancreatic cancer , monoclonal antibody , chemistry , apoptosis , in vitro , flow cytometry , pancreatic tumor , pharmacology , antibody , microbiology and biotechnology , cancer research , cancer , mucin , medicine , biology , immunology , biochemistry
Previous studies have discovered a high expression rate of Mucin 1 (MUC1) in pancreatic cancer tissue, and its abnormal glycosylation causes MUC1 to expose new protein epitopes or glycoantigens.