Open AccessInhibitory effect of Bowman–Birk protease inhibitor on autophagy in MDAMB231 breast cancer cell line
Author(s) -
Sudabeh Kyani,
Hassan Akrami,
Ali Mostafaei,
Samaneh Akbari,
Zohreh Salehi
Publication year - 2021
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_622_18
Subject(s) - autophagy , atg5 , apoptosis , mtt assay , cell culture , protease , viability assay , cell growth , cancer , programmed cell death , biology , cancer cell , cell cycle , microbiology and biotechnology , cell , protease inhibitor (pharmacology) , cancer research , chemistry , biochemistry , immunology , enzyme , genetics , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load
Autophagy has an essential role in cellular energetic balance, cell cycle, and cell death, so the change in autophagy level is crucial in many human diseases such as cancer. Herbal medicine has been widely used to treat cancer. Bowman-Birk protease inhibitor (BBI), a protease inhibitor extracted from soybean, has antitumorigenic, anti-inflammatory, and anti-angiogenic activities. In this study, we evaluated the effect of BBI on the growth of breast cancer cell line and transcript level of autophagy and apoptosis-related genes.