Open AccessRole of glutathione S-transferase P1 polymorphism in early transplant complications in patients undergoing allogeneic stem cell transplantation
Author(s) -
Hazen Sarıtaş,
Elif Suyanı,
Sezen Güntekin,
Aki Şahika Zeynep,
Mehmet Ali Ergün,
Bülent Çelik,
Gülsan Türköz Sucak
Publication year - 2021
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_61_20
Subject(s) - gstp1 , gastroenterology , hematopoietic stem cell transplantation , transplantation , medicine , transferrin saturation , anemia , genotype , biology , iron deficiency , biochemistry , gene
Complications in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) cause serious morbidity and mortality. Predicting patients at risk in advance and changing the symptomatic care and/or preparation regimen according to this risk assessment have been emphasized recently. Several single-nucleotide polymorphisms have been studied, and some were found to be responsible for early complications. Glutathione S-transferase P1 (GSTP1) is an enzyme involved in the detoxification process that reduces oxidative stress by reducing the number of free oxygen radicals.