Open AccessThe role of pyroptosis in lung cancer and compounds regulated pyroptosis of lung cancer cells
Author(s) -
Feng Tian,
Xueyang Chen,
Ke Yin,
Xiaoyan Lin,
Yonghui Song
Publication year - 2021
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_614_21
Subject(s) - pyroptosis , lung cancer , programmed cell death , cancer research , microbiology and biotechnology , cytosol , chemistry , cancer cell , cancer , apoptosis , medicine , biology , enzyme , biochemistry , pathology
Pyroptosis is a caspase-1/3/4/5/8/11-mediated form of programmed cell death. It is primarily induced through two pathways - the canonical and noncanonical pathways. Following enzymatic cleavage, gasdermin D, a key substrate for pyroptosis, releases N-terminal fragments that form pores on the plasma membrane, triggering osmotic lysis, and eventually releases cytosolic material to trigger inflammatory responses. Various pyroptotic pathway mediators are involved in lung cancer initiation, proliferation, migration, and invasion, and an increasing number of anticancer compounds have been developed by regulating the pyroptotic pathway. This review aims to summarize recent progress in the understanding of the molecular mechanisms of pyroptosis and the association between pyroptotic-related molecules and lung cancer. Moreover, we discussed more than 10 compounds that exerted antitumor properties by inducing pyroptosis of lung cancer cells.