Open AccessExpression of epithelial–mesenchymal transition biomarkers: Discoidin domain receptor 2, Snail-1, and Ovol-2 as predictors of clinical outcome in patients with epithelial ovarian carcinoma
Author(s) -
OlaA. Harb.,
MariemA. Elfeky.,
Wafaa El-Beshbishi,
AhmedA Obaya,
WaelM Abdallah,
Amr Ibrahim,
AmrA Awd,
Ahmed Embaby
Publication year - 2022
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_605_19
Subject(s) - discoidin domain , snail , medicine , immunohistochemistry , oncology , epithelial–mesenchymal transition , progesterone receptor , estrogen receptor , receptor tyrosine kinase , stage (stratigraphy) , tumor progression , cancer , cancer research , metastasis , biology , receptor , breast cancer , ecology , paleontology
Discoidin domain receptor 2 (DDR-2), which belongs to the receptor tyrosine kinase family, Snail-1, which is a member of zinc-finger transcription factor family, and Ovol-2, which is a member of Ovol family, are incriminated in epithelial-mesenchymal transition (EMT) during cancer progression.