Open AccessTransforming growth factor-β1 gene polymorphism as a potential risk factor in Turkish patients with laryngeal squamous cell carcinoma
Author(s) -
Candan Demiröz Abakay,
Mehrdad Pashazadeh,
Elif Ardahanli,
Haluk Barbaros Oral
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_598_19
Subject(s) - genotype , turkish population , genotyping , cytokine , allele , biology , gene , transforming growth factor , allele frequency , cancer research , immunology , cancer , medicine , genetics
Laryngeal cancer is the most common head-and-neck malignancies with more than 20% of all cases. The vast majority of tumors are squamous cell carcinoma (SCC). Several genes encoding different cytokines may play crucial roles in host susceptibility to cancer because cytokine production capacity varies among individuals and depends on cytokine gene polymorphisms.