Open AccessEvaluation of circulating miR-21 and miR-222 as diagnostic biomarkers for gastric cancer
Author(s) -
Sahar Sarmasti Emami,
Reza Negarandeh,
Abolfazl Akbari,
Amirhossein Faraji,
Vida Abbasi,
Shahram Agah
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_592_17
Subject(s) - microrna , cancer , biomarker , real time polymerase chain reaction , receiver operating characteristic , diagnostic biomarker , cancer research , bioinformatics , medicine , gene , oncology , biology , genetics
Gastric cancer is responsible for a large number of death worldwide and its high death rate is associated with a lack of noninvasive tools in GC diagnosis. MicroRNAs (miRNAs), as gene regulators, were shown to dysregulate in different types of cancer. Moreover, it is proven that miRNAs are stable in serum/plasma, so they can be used as a potential noninvasive marker in GC diagnosis. The objective of this study is to investigate the plasma miRNA expression in GC samples compared to controls as a potential biomarker in cancer diagnosis.