Open AccessA study on the frequency and clinicopathological correlates of mismatch repair-deficient colorectal cancer
Author(s) -
R Paraashar,
Nishitha Shetty,
R Pareekshith,
Dinesh Shet,
Arpitha Shetty
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_526_18
Subject(s) - mlh1 , microsatellite instability , msh2 , colorectal cancer , medicine , lymphovascular invasion , pms2 , dna mismatch repair , oncology , lynch syndrome , perineural invasion , cancer , msh6 , pathology , biology , metastasis , microsatellite , genetics , allele , gene
Microsatellite instability is an important pathway of tumorigenesis in colorectal cancer, and there is a need to understand its genetic and phenotypic profile. This study aimed to study the occurrence of deficient mismatch repair (dMMR) in an Indian cohort of patients and document the corresponding clinicopathological correlates.