Open AccessRegulation of XPA could play a role in inhibition of radiation-induced bystander effects in QU-DB cells at high doses
Author(s) -
Mohammad Taghi Bahreyni Toossi,
Hosein Azimian,
Shokouhozaman Soleymanifard,
Habibeh Vosoughi,
Elham Dolat,
Abdul Rahim Rezaei,
Sara Khademi
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_503_18
Subject(s) - bystander effect , microbiology and biotechnology , dna repair , apoptosis , gene expression , dna damage , biology , gene , dna , transcription (linguistics) , chemistry , genetics , immunology , linguistics , philosophy
Radiation-induced bystander effects (RIBE) is the radiobiological effects detected in nonirradiated cells that have received signals from neighboring irradiated cells. In some studies, there are observations that RIBE unexpectedly reduces at high doses. In this study, the expression of two selected apoptotic and repair genes and their possible role in the formation of this unexpected reduction is examined.