Open AccessComparison of hazard models with and without consideration of competing risks to assess the effect of neoadjuvant chemotherapy on locoregional recurrence among breast cancer patients
Author(s) -
Mona Pathak,
Surya Narayana V S. Deo,
Sada Nand Dwivedi,
Sreenivas Vishnubhatla,
Bhaskar Thakur
Publication year - 2021
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_49_19
Subject(s) - medicine , hazard ratio , proportional hazards model , breast cancer , oncology , confidence interval , retrospective cohort study , cumulative incidence , radiation therapy , cancer , surgery , cohort
While analyzing locoregional recurrences (LRRs), it is necessary to consider distant metastasis as a competing event. Because, later one is more fatal than LRR. It may change ongoing treatment of breast cancer and may alter the chance of LRR. Although some earlier studies assessed the effect of neoadjuvant chemotherapy (NACT) on LRR, they did not use competing risk regression model for it.