Open AccessCombined effect of 125I and gemcitabine on PANC-1 cells: Cellular apoptosis and cell cycle arrest
Author(s) -
Dong Li,
Yunming Jia,
Pikun Cao,
Wei Wang,
Bin Liu,
Yuliang Li
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_43_18
Subject(s) - gemcitabine , clonogenic assay , apoptosis , cell cycle , cell cycle checkpoint , cancer research , cell growth , in vitro , pancreatic cancer , chemistry , medicine , chemotherapy , oncology , pharmacology , cancer , biochemistry
125 I seed implantation has recently become an effective, safe, and feasible treatment for advanced pancreatic cancer in China. Gemcitabine (GEM), superior to fluorouracil, has been widely proved as effective chemotherapy for many solid tumors and become the standard treatment for locally advanced and metastatic pancreatic cancer. The study aimed to evaluate the combined effect of 125 I and GEM on pancreatic carcinoma cells (PANC-1) cells and explore the underlying molecular basis.