Open AccessDownregulation of human leukocyte antigen Class I expression: An independent prognostic factor in colorectal cancer
Author(s) -
Ehsan NazemalhosseiniMojarad,
Hamid AsadzadehAghdaei,
Somayeh Mohammadpour,
Amir Torshizi Esfahani,
Mohammad Amin Porhoseingholi,
Mahsa Molaei,
Amir Jalali,
Peter J.K. Kuppen,
Mohammad Reza Zali
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_429_18
Subject(s) - microsatellite instability , colorectal cancer , kras , human leukocyte antigen , cancer , hazard ratio , oncology , univariate analysis , medicine , immunohistochemistry , cancer research , microsatellite , antigen , biology , multivariate analysis , immunology , gene , genetics , allele , confidence interval
In the present study, we evaluated the clinical prognostic value of human leukocyte antigen (HLA (Class I tumor cell expression in a series of colorectal cancer (CRC) patients and also explored the association of this expression profile with molecular features such as mutation status of KRAS and BRAF, microsatellite stability status, and clinicopathological characteristics of the patients.