Open AccessOsteoclastic variant of anaplastic thyroid carcinoma
Author(s) -
Divya Shelly,
Divya Gupta,
S. K. Mishra,
Reena Bharadwaj
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_355_16
Subject(s) - giant cell , multinucleate , pathology , malignancy , thyroid , anaplastic carcinoma , goiter , medicine , thyroid carcinoma , carcinoma , osteoclast , cancer research , receptor
Anaplastic thyroid carcinoma (ATC) is a rare, highly malignant thyroid tumor with dismal prognosis. Osteoclastic giant cell variant of ATC is extremely rare and is characterized by the presence of a large number of multinucleated giant cells resembling osteoclasts. We report here this unusual variant in a 67-year-old female with a history of long-standing goiter of 13 years duration. Histologically, many multinucleated osteoclast-like giant cells were seen accompanying the malignant spindle cell component. Despite extensive sampling, no evidence of differentiated thyroid malignancy could be elucidated.