Open AccessInterleukin 10 promotes growth and invasion of glioma cells by up-regulating KPNA 2 in vitro
Author(s) -
Zihao Zhang,
Xiaoming Huang,
Jie Li,
Haitao Fan,
Fan Yang,
Rui Zhang,
Yihang Yang,
Shaobin Feng,
He Dong,
Wei Sun,
Tao Xin
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_284_19
Subject(s) - glioma , gene knockdown , downregulation and upregulation , cancer research , cell growth , biology , cytokine , interleukin 10 , cell , tumor progression , apoptosis , immunology , cancer , gene , biochemistry , genetics
Glioma is one of the leading causes of death worldwide with high incidence, recurrence, and mortality. Interleukin-10 (IL-10) is a cytokine with dual function in many types of tumors. Although IL-10 is overexpressed and promotes tumor progression in human primary brain tumor, the mechanisms are largely unknown.