Open AccessA study of BRAF mutation in colorectal carcinoma in Indian population
Author(s) -
Shivam Saxena,
V. Srinivas,
Prabal Deb,
Deep Kumar Raman,
Rajat Jagani
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_26_17
Subject(s) - medicine , mutation , colorectal cancer , oncology , population , germline mutation , cancer , cancer research , biology , genetics , gene , environmental health
BRAF mutation has been extensively studied and associated with various tumors. Targeted therapeutic intervention against BRAF mutation is established modality against many such tumors. Various studies have estimated that the prevalence of BRAF mutation in colorectal carcinoma (CRC) is 5%-25%. Considering epidemiology differences from Western population and paucity of studies on BRAF mutation in CRC in Asian patients, the present study was done to study the BRAF mutation in CRC in Indian population.