Open AccessImpact of stromal CD45RO+ immune cells on proliferation and dedifferentiation in node-negative squamous cell carcinomas of cheek mucosa
Author(s) -
Vijay Wadhwan,
Arvind Venkatesh,
Pooja Aggarwal,
Vandana Reddy,
Preeti Sharma,
Suhasini Gotur Palakshappa
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_263_16
Subject(s) - immune system , stromal cell , immunohistochemistry , pathology , biology , lymph node , cheek , cancer research , immunology , medicine , anatomy
The most fundamental trait of cancer cells involves their ability to sustain chronic proliferation. Tumors have a complex cellular ecology that establishes the malignant potential of the tumor. In these ecosystems, innate immune cells are highly represented. Many contradictory reports have been published regarding the impact of tumor-infiltrating immune cells on proliferation of the tumors.