Open AccessBlocking of methionine aminopeptidase-2 by TNP-470 induces apoptosis and increases chemosensitivity of cholangiocarcinoma
Author(s) -
Sonexai Kidoikhammouan,
Wunchana Seubwai,
Atit Silsirivanit,
Sopit Wongkham,
Kanlayanee Sawanyawisuth,
Chaisiri Wongkham
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_250_17
Subject(s) - apoptosis , propidium iodide , cisplatin , cancer research , doxorubicin , gemcitabine , cell cycle , cell growth , flow cytometry , chemistry , cell culture , pharmacology , cancer , biology , chemotherapy , programmed cell death , microbiology and biotechnology , medicine , biochemistry , genetics
Resistance of cancer cells to chemotherapeutic drugs is a major pitfall of the failure of chemotherapy treatment for cholangiocarcinoma (CCA). A new therapeutic strategy that can improve treatment efficacy is mandatory for CCA patients. Our previous findings demonstrated the overexpression of methionine aminopeptidase-2 (MetAP2) in CCA patients. In addition, supplementation of TNP-470, a MetAP2 inhibitor, significantly inhibited the growth and metastatic activities of CCA cell lines. However, the molecular mechanism of antitumor activity of TNP-470 and the synergistic antitumor activity of TNP-470 combined with chemotherapeutic drugs are still unknown.