Open AccessA practical screening strategy for Lynch syndrome and Lynch syndrome mimics in colorectal cancer
Author(s) -
Zhigang Yao,
Beibei Lv,
Hao Jing,
Wenjing Su,
Jiamei Li,
Hongbo Fan,
Mingqiu Zhao,
Yejun Qin,
Xiao Sun
Publication year - 2021
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_214_21
Subject(s) - lynch syndrome , mlh1 , dna mismatch repair , medicine , colorectal cancer , germline mutation , oncology , family history , genetic testing , microsatellite instability , gene mutation , cancer , mutation , genetics , gene , biology , microsatellite , allele
The objective of the study is to provide an efficient and practical screening strategy to distinguish a broader spectrum of Lynch syndrome (LS) and LS mimics-associated colorectal cancer (CRC), including Lynch-like syndrome (LLS), constitutional mismatch repair-deficiency, familial CRC type X (FCCTX), and polymerase proofreading-associated polyposis syndrome.