Open AccessApplication of dextran-coated iron oxide nanoparticles in enhancing the radiosensitivity of cancerous cells in radiotherapy with high-energy electron beams
Author(s) -
Masoud Rezaei,
Karim Khoshgard,
Leila Hosseinzadeh,
Abbas Haghparast,
Mohammad-Taghi Eivazi
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_19_17
Subject(s) - hela , radiosensitivity , radiosensitizer , cytotoxicity , cell culture , irradiation , in vitro , apoptosis , nanoparticle , chemistry , radiochemistry , cancer research , radiation therapy , materials science , medicine , nanotechnology , biology , biochemistry , physics , nuclear physics , genetics
Nowadays, cancer is one of the most important causes of morbidity and mortality in the world. The ideal aim of radiotherapy is delivering a lethal radiation dose to tumor cells while minimizing radiation exposure to healthy tissues around the tumor. One way to increase the dose in the tumor cells is the use of high-atomic number nanoparticles as radiosensitizer agents in these cells. The aim of this in vitro study was investigating the radiosensitization enhancement potential of the dextran-coated iron oxide nanoparticles (IONPs) on HeLa and MCF-7 cell lines in irradiations with high-energy electron beams.